| ORIGINAL ARTICLE |
|
| Year : 2020 | Volume
: 4
| Issue : 1 | Page : 2-7 |
|
|
Serum nonenzymatic anti-oxidants in Nigerian children with severe pneumonia: Association with complications and hospital outcomes
Bankole Peter Kuti, Oyeku Akibu Oyelami
Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria
Correspondence Address:
Bankole Peter Kuti
Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/prcm.prcm_7_20
|
|
|
Background: Tissue damaging effects of free radicals generated during the acute inflammation processes of childhood pneumonia may be ameliorated by antioxidants. This study aimed to determine the serum non-enzymatic antioxidants {Total Phenols, Carotenoids, Flavoids, Ascorbic acid, Tocopherols and Total Antioxidant Contents (TAC)} of Nigerian children with or without severe pneumonia (SP) and relate these to the presence of parapneumonic effusions (PPE) and length of hospitalisation (LOH). Methods: Consecutive children two months to 14 years admitted with severe pneumonia and their age and sex matched controls were recruited over a 12-month period at a Nigerian Health facility. Serum antioxidants were assayed using chromatography method and related to PPE and LOH. Results: The majority (86.1%) of the 144 children (72 each with SP and controls) were under-fives and eight (11.1%) of SP group had PPE. Median (IQR) LOH was 5.0 (4.0 – 7.0) days and 45 (62.5%) had prolonged (≥5 days) hospital stay with 3 (4.2%) mortality. Serum Tocopherols, 10.1 (4.7) vs. 13.2 (7.6) µg/dl; total flavoids 1.0 (0.6) vs. 1.3 (0.8) µg/dl and TAC 6.1 (4.4-8.9) vs. 7.4 (5.0 – 13.3) ng/dl were significantly lower in children with SP (p < 0.05). Serum antioxidants levels were not related to the PPE, however children with prolonged LOH had lower TAC (p<0.05), which also correlated negatively with LOH (r =- 0.418; p < 0.001) Conclusion: Lower serum antioxidants observed in children with severe pneumonia may connote increased demand or increased predisposition to the infection. Antioxidant supplementation may aid recovery of Nigerian children with SP.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
